Sastojci

Sastojci u LaKOTA MEN'S FORMULi

Beta Sitosterol – Jedan je od biljnih sterola, a brojne kliničke studije potvrđuju da beta sitosterol olakšava simptome uzrokovane benignom hiperplazijom prostate (BHP).  Istraživanja upućuju da beta-sitosterol vjerojatno djeluje na uvećanu prostatu tako što inhibira enzim 5-alfa-reduktazu, blokirajući pretvorbu testosterona u dihidrotestosteron (DHT), te na taj način smanjuje razinu DHT-a u tijelu. 

Studije

  1. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group.  Berges RR, Windeler J, Trampisch HJ, Senge T. Lancet. 1995 Jun 17;345(8964):1529-32
  2. Beta-sitosterols for benign prostatic hyperplasia. Wilt T, Ishani A, MacDonald R, Stark G, Mulrow C, Lau J. Cochrane Database Syst Rev. 2000;(2):CD001043. Review.
  3. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. Wilt TJ, MacDonald R, Ishani A. BJU Int. 1999 Jun;83(9):976-83. Review.
  4. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group. Klippel KF, Hiltl DM, Schipp B. Br J Urol. 1997 Sep;80(3):427-32.
  5. Treatment of symptomatic benign prostatic hyperplasia with b-sitosterol: an 18-month follow-up.  Berges RR, Kassen A,  Senge T.  BJU International (2000), 85, 842±846

Kopriva  - U preko 20 kliničkih studija dokazano je da kopriva u kombinaciji sa drugim biljkama dovodi do olakšanja kod kliničih simpotma benigne hiperplazije prostate i prostatitisa.  Kopriva usporava pretvaranje  testosterona u 5-alfa-reduktazu, enzim koji uzrokuje početak uvećanja prostate nakon 40. godine.  Ne smanjuje uvećanu prostatu, ali povećava protok kroz uretru.

Studije

  1. 1.Lopatkin, N. A., et al. "Combined extract of Sabal palm and nettle in the treatment of patients with lower urinary tract symptoms in double blind, placebo-controlled trial." Urologiia. 2006 Mar-Apr; 12(2): 14-9.
  2. Safarinejad, M. R., "Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study." J. Herb Pharmacother. 2005; 5(4): 1-11.
  3. Popa, G., et al. “Efficacy of a combined Sabal-urtica preparation in the symptomatic treatment of benign prostatic hyperplasia. Results of a placebo-controlled double-blind study.” MMW Fortschr. Med. 2005 Oct; 147 Suppl 3:103-8.
  4. Lopatkin, N., et al. “Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms--a placebo-controlled, double-blind, multicenter trial.” World J. Urol. 2005 Jun; 23(2): 139-46.
  5. Walther, C., et al. "Benign prostatic syndrome. Urinary urgency and micturition frequency reduced with plant preparation." MMW Fortschr. Med. 2005 Oct; 147(40): 52-3.
  6. Popa, G., et al. “Benign prostate syndrome: urinary tract symptoms can be eased with phytotherapy.” MMW Fortschr. Med. 2005 Aug; 147(33-34):42.
  7. Schneider, T., et al. “Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome (BPS). Results of a randomized, double-blind, placebo controlled multicenter study after 12 months” Urologe A. 2004 Mar;43(3):302-6.
  8. Durak I, et al. “Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer.” Cancer Biol. Ther. 2004; 3(9): 855-7.
  9. Carson, C., et al. “The role of dihydrotestosterone in benign prostatic hyperplasia.” Urology. 2003; 61(4 Suppl 1): 2-7.
  10. Melo, E. A., et al. “Evaluating the efficiency of a combination of Pygeum africanum and stinging nettle (Urtica dioica) extracts in treating benign prostatic hyperplasia (BPH): double-blind, randomized, placebo controlled trial.” Int. Braz. J. Urol. 2002 Sep-Oct; 28(5): 418-25.
  11. Koch, E. “Extracts from fruits of saw palmetto (Sabal serrulata) and roots of stinging nettle (Urtica dioica): viable alternatives in the medical treatment of benign prostatic hyperplasia and associated lower urinary tracts symptoms.” Planta Med. 2001; 67: 489-500.
  12. Sokeland, J. “Combined sabal and urtica extract compared with finasteride in men with benign prostatic hyperplasia: analysis of prostate volume and therapeutic outcome.” B. J. U. Int. 2000; 86(4): 439-42.
  13. Schottner, M., et al. “Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).” Planta Med. 1997; 63(6): 529-32.
  14. Lichius, J. J., et al. “The inhibiting effects of Urtica dioica root extracts on experimentally induced prostatic hyperplasia in the mouse.” Planta Med. 1997; 63(4): 307-10.
  15. Hryb, D. J., et al. “The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes.” Planta Med. 1995; 61(1): 31-2.
  16. Koch E. and A. Biber. "Pharmacological effects of saw palmetto and urtica extracts for benign prostatic hyperplasia." Urologe 1994; 34(2): 90-95.
  17. Krzeski, T., et al. “Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses.” Clin. Ther. 1993; 15(6): 1011-20.

Kvercetin – Ova tvar se smatra pretečom i predstavnikom svih bioflavonoida zbog toga što je njegova kemijska struktura osnovni "skelet" većine drugih bioflavonoida, uključujući rutin, hesperidin i dr. Neki znanstvenici ga zovu još i kraljem flavonoida.  Osim što je dobar protuupalni agens, kvercetin je dokazano i jak antioksidant, te je pokazao svoje pozitivno i raznovrsno djelovanje na ljudski organizam. 

Što se tiče prostate postoje znanstvena istraživanja koja pokazuju da kvercetin može smanjiti simptome kod kroničnog prostatitisa, te se zato i koristi kao jedna od alternativa za tretiranje ovakog stanja kod muškaraca.

Studije

  1. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial.  Shoskes DA, Zeitlin SI, Shahed A, Rajfer J.  Urology. 1999 Dec, 54(6): 960-3.
  2. Phytotherapy in chronic prostatitis.  Shoskes DA.  Urology.  2002 Dec, 60(60): 35-7.
  3. Long-term Results of Multimodal Therapy for Chronic Prostatitis/chronic Pelvic Pain Syndrome.  Shoskes DA, Hakim L, Ghoniem G, Jackson CL.  J Urol. 2003 April; 169(4):1406-10.
  4. Phytotherapy and other alternative forms of care for the patient with prostatitis.  Shoskes DA.  Curr Urol Rep. 2002 Aug;3(4):330-4.
  5. Herbal and complementary medicine in chronic prostatitis.  Shoskes DA, Manickam K.  World J Urol. 2003 Jun;21(2):109-13. Epub 2003 Apr 29. Review.
  6. New therapies in chronic prostatitis.  Dhar NB, Shoskes DA.  Curr Urol Rep. 2007 Jul;8(4):313-8. Review.

Sabal palma – Već se tradicionalno koristi za ublažavanje simptoma uzrokovanih benignom hiperplazijom prostate (BHP), što potvrđuju i mnogobrojne znanstvene studije.  Ova biljka isto posjeduje inhibitorna svojstva na 5-alfa-reduktazu (na taj način preventirajući pretvorbu testosterona u dihidrotestosteron (DHT)).

Studije

  1. Serenoa repens extract in the treatment of benign prostatic hyperplasia. Geavlete P, Multescu R, Geavlete B. Ther Adv Urol. 2011 Aug;3(4):193-8.
  2. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic.  hyperplasia. Marks LS, Partin AW, Epstein JI, Tyler VE, Simon I, Macairan ML, Chan TL, Dorey FJ, Garris JB, Veltri RW, Santos PB, Stonebrook KA, deKernion JB. J Urol. 2000 May;163(5):1451-6
  3. Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms. Gerber GS, Kuznetsov D, Johnson BC, Burstein JD. Urology. 2001 Dec;58(6):960-4; discussion 964-5.
  4. Saw palmetto (Serenoa repens) in men with lower urinary tract symptoms: effects on urodynamic parameters and voiding symptoms.Gerber GS, Zagaja GP, Bales GT, Chodak GW, Contreras BA. Urology. 1998 Jun;51(6):1003-7.
  5. Saw palmetto for the treatment of men with lower urinary tract symptoms. Gerber GS. J Urol. 2000 May;163(5):1408-12. Review.
  6. Saw Palmetto and Benign Prostatic Hyperplasia.  Gong EM and Gerber GS.  The American Journal of Chinese Medicine, Vol. 32, No. 3, 331–338

Sjemenke buće – Još jedan biljni sastojak koji je poznat po svom učinku na smanjenje simptoma uzrokovanim benignom hiperplazijom prostate (BHP).  To nam pokazuju studije na ljudima i životinjama.  Pokazalo se da i sjemenke buće kao i sabal palma djeluju inhibitorno na pretvorbu testosterona u dihidrotesteron (DHT).

Studije

  1. Inhibition of testosterone-induced hyperplasia of the prostate of sprague-dawley rats by pumpkin seed oil. Gossell-Williams M, Davis A, O'Connor N. J Med Food. 2006 Summer;9(2):284-6.
  2. Treatment of benign prostatic hyperplasia with phytosterols. Carbin BE, Larsson B, Lindahl O. Br J Urol. 1990 Dec;66(6):639-41
  3. Herbs for benign prostatic hyperplasia. Dvorkin L, Song KY. Ann Pharmacother. 2002 Sep;36(9):1443-52. Review.
  4. Herbal Drugs in the Treatment of Benign Prostatic Hyperplasia. H. Schilcher. Phytomedicines of Europe Chapter 6, pp 62–73
  5. Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia.  Hong H, Kim CS, Maeng S.  Nutr Res Pract. 2009 Winter;3(4):323-7.

Pirika – Ova biljka pomaže urinarnom sustavu ne samo tako što potiče protok urina, nego što i ublažava upaljenu membranu sluznice i iritaciju urinarnih puteva.

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